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Intramyocardial gene transfer of vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

dc.creatorOjalvo,Ariana G
dc.creatorSeralena,Alina
dc.creatorVispo,Nelson S
dc.creatorSilva,Ricardo
dc.creatorGonzalez,Noel
dc.creatorGuevara,Luis
dc.creatorBatista,Juan F
dc.creatorMontequin,Jose F.
dc.creatorChaos,Nicolas
dc.creatorGonzález,Rafael
dc.creatorReima,Camilo
dc.creatorPeña,Yamile
dc.creatorCoca,Marcos
dc.creatorPerera,Alejandro
dc.creatorVazquez,Raysa
dc.creatorPuchades,Yaquelin
dc.creatorGarcia-Osuna,Tamara
dc.creatorDominguez,Heberto
dc.creatorReyes,Jose L.
dc.creatorAli,Alfonso
dc.creatorHerrera,Luis
dc.date2004-12-01
dc.date.accessioned2019-05-03T12:44:09Z
dc.date.available2019-05-03T12:44:09Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582004000300008
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/84793
dc.descriptionVascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. Several studies report on gene transfer of VEGF121 to promote angiogenesis in the ischemic myocardium of animals and patients. We hypothesized that intramyocardial administration of naked plasmid DNA encoding VEGF121 could improve myocardial perfusion and function in a porcine model of myocardial ischemia. Yorkshire swine underwent thoracotomy and placement of an ameroid constrictor on the circumflex coronary artery. Four weeks later, pVEGF121 plasmid was administered into the ischemic myocardium. Four weeks after gene transfer, SPECT imaging demonstrated significant reduction in the ischemic area in pVEGF121-treated animals compared with controls. In the pVEGF121 group, most of the animals evolved from light ischemia to a normal perfusion. In contrast, control animals exhibited similar or impaired ischemic conditions. Our results indicate that intramyocardial gene transfer of VEGF121 as naked plasmid DNA results in significant improvement in myocardial perfusion and function.
dc.formattext/html
dc.languageen
dc.publisherPontificia Universidad Católica de Valparaíso
dc.relation10.4067/S0717-34582004000300008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceElectronic Journal of Biotechnology v.7 n.3 2004
dc.titleIntramyocardial gene transfer of vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart


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