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  • Electronic Journal of Biotechnology
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  • Pontificia Universidad Católica de Valparaíso
  • Electronic Journal of Biotechnology
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Silanol - A novel class of antimicrobial agent

Author
Kim,Yun-mi

Farrah,Samuel

Baney,Ronald H.

Full text
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582006000200012
Abstract
Recently, a significant amount of attention has been directed toward development of novel classes of biocides because of the potential for microbial contamination and infection risks to military personnel and in the general population. We have recently discovered a new and unexpected class of powerful biocides based upon compounds derived through simple chemistry from silicone intermediates, "silicon alcohols" called, silanols. One example is trialkylsilanols, R3SiOH. Antimicrobial tests were carried out against Gram-negative bacterium, Escherichia coli, and Gram-positive, Staphylococcus aureus, with silanols, t-butanol, and siloxanes. Trialkylsilanols were very effective biocides against Escherichia coli and Staphylococcus aureus. The number of viable bacteria reduced was more than eight orders of magnitude with silanol treatments. Triethylsilanol, in particular, exhibited a strong antimicrobial effect at a very low concentration within 10 min. These novel biocide silanols can be prepared from low cost intermediates derived from the commercial processesassociated with the silicone industry. Silanols are considered environmentally benign because of their transitory nature and ultimate conversion to CO2, SiO2, and H2O.
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Discipline
Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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