Show simple item record

dc.creatorMarini,Guillermo
dc.creatorForno,Guillermina
dc.creatorKratje,Ricardo
dc.creatorEtcheverrigaray,Marina
dc.date2007-04-01
dc.date.accessioned2019-05-03T12:44:25Z
dc.date.available2019-05-03T12:44:25Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000200011
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/84950
dc.descriptionThe pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. Each route of administration gave a different rhGM-CSF concentration-time profile. After extra vascular administration of equivalent doses, a higher peak concentration and faster elimination were observed in the group treated with the E. coli-derived cytokine. The faster elimination resulted in a return to pre-treatment plasma levels after 12 hrs, versus 48 hrs following the administration of glycosylated rhGM-CSF. After intravascular administration, clearance of rhGM-CSF was significantly decreased by the presence of carbohydrates. Non-significant differences in the terminal phase of the biphasic kinetics were found, but the distribution phase was significantly longer for the glycosylated form
dc.formattext/html
dc.languageen
dc.publisherPontificia Universidad Católica de Valparaíso
dc.relation10.4067/S0717-34582007000200011
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceElectronic Journal of Biotechnology v.10 n.2 2007
dc.subjectglycosylation
dc.subjectpharmacokinetic parameters
dc.subjectrhGM-CSF
dc.titleRecombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters


This item appears in the following Collection(s)

Show simple item record