Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276

dc.creator	Ramírez,Mario A.
dc.creator	Pérez,Herminia I.
dc.creator	Manjarrez,Norberto
dc.creator	Solís,Aida
dc.creator	Luna,Héctor
dc.creator	Cassani,Julia
dc.date	2008-10-01
dc.date.accessioned	2019-05-03T12:44:32Z
dc.date.available	2019-05-03T12:44:32Z
dc.identifier	https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002
dc.identifier.uri	http://revistaschilenas.uchile.cl/handle/2250/85029
dc.description	Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.
dc.format	text/html
dc.language	en
dc.publisher	Pontificia Universidad Católica de Valparaíso
dc.relation	10.4067/S0717-34582008000400002
dc.rights	info:eu-repo/semantics/openAccess
dc.source	Electronic Journal of Biotechnology v.11 n.4 2008
dc.subject	4-chlorobenzophenone
dc.subject	biocatalysis
dc.subject	microbial oxidation
dc.subject	resolution
dc.title	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276