| dc.creator | Vilos,Cristian | |
| dc.creator | Constandil,Luis | |
| dc.creator | Herrera,Natalia | |
| dc.creator | Solar,Paula | |
| dc.creator | Escobar-Fica,Jorge | |
| dc.creator | Velásquez,Luis Alberto | |
| dc.date | 2012-07-01 | |
| dc.date.accessioned | 2019-05-03T12:44:58Z | |
| dc.date.available | 2019-05-03T12:44:58Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000400001 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/85278 | |
| dc.description | Background: The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. The formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. Accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. Results: In this work, we formulated ceftiofur-loaded PHBV microparticles (PHBV-CEF) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. The encapsulation efficiency was 39.5 ± 1.1% w/w, and we obtained a sustained release of ceftiofur in PBS-buffer (pH 7.4) over 7 days. The antibacterial activity of ceftiofur was preserved after the encapsulation procedure, and toxicity of PHBV-CEF microparticles evaluated by MTS was represented by an IC50 > 10 mg/mL. Conclusions: Our results suggest that PHBV-CEF particles have a potential application for improving the treatment of infectious diseases in the livestock breeding industry. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Pontificia Universidad Católica de Valparaíso | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Electronic Journal of Biotechnology v.15 n.4 2012 | |
| dc.subject | ceftiofur | |
| dc.subject | drug delivery | |
| dc.subject | livestock breeding industry | |
| dc.subject | PHBV | |
| dc.subject | polymeric microparticles | |
| dc.title | Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections | |
