| dc.creator | Liu,Chang | |
| dc.creator | Zhang,Jing | |
| dc.creator | Yifeng,E | |
| dc.creator | Yue,Jingli | |
| dc.creator | Chen,Lianshan | |
| dc.creator | Li,Donghui | |
| dc.date | 2014-07-01 | |
| dc.date.accessioned | 2019-05-03T12:45:12Z | |
| dc.date.available | 2019-05-03T12:45:12Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582014000400007 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/85422 | |
| dc.description | Background A simple, rapid, low-cost and environmentally friendly method was developed to determine dopamine (DA) in the presence of ascorbic (AA) and uric acid (UA) based on a novel technique to prepare a graphene-chitosan (GR-CS) nanocomposite and modify it on the surface of carbon paste electrode (CPE). For our design, CS acts as a media to disperse and stabilize GR, and then GR plays a key role to selective and sensitive determination of DA. Results Under physiological conditions, the linear range for dopamine was determined from 1 × 10- 4 to 2 × 10- 7 mol/L with a good correlation coefficient of 0.9961 in the presence of 1000-fold interference of AA and UA. The detection limit was estimated to be 9.82 × 10- 8 mol/L (S/N = 3). In order to study the stability and reproducibility, GR/CS/CPE underwent successive measurements in 10 times and then tested once a d for 30 d. The result exhibited 98.25% and 91.62% activities compared with the original peak current after 10-time measurements and 30-d storage. Conclusion The GR/CS/CPE has wide linear concentration range, low detection limit, and good reproducibility and stability, which suggests that our investigations provide a promising alternative for clinic DA determination. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Pontificia Universidad Católica de Valparaíso | |
| dc.relation | 10.1016/j.ejbt.2014.04.013 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Electronic Journal of Biotechnology v.17 n.4 2014 | |
| dc.subject | Dopamine | |
| dc.subject | Selective determination | |
| dc.subject | Surface modification of carbon paste electrode | |
| dc.subject | Technique of one-pot synthesis | |
| dc.title | One-pot synthesis of graphene-chitosan nanocomposite modified carbon paste electrode for selective determination of dopamine | |
