Diet high in &#945;-linolenic acid up-regulate PPAR-&#945; gene expression in the liver of goats

Ebrahimi,Mahdi; Rajion,Mohamed Ali; Meng,Goh Yong; Farjam,Abdoreza Soleimani; Oskoueian,Ehsan; Jafari,Saeid

dc.creator	Ebrahimi,Mahdi
dc.creator	Rajion,Mohamed Ali
dc.creator	Meng,Goh Yong
dc.creator	Farjam,Abdoreza Soleimani
dc.creator	Oskoueian,Ehsan
dc.creator	Jafari,Saeid
dc.date	2015-05-01
dc.date.accessioned	2019-05-03T12:45:17Z
dc.date.available	2019-05-03T12:45:17Z
dc.identifier	https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000300011
dc.identifier.uri	http://revistaschilenas.uchile.cl/handle/2250/85479
dc.description	Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.
dc.format	text/html
dc.language	en
dc.publisher	Pontificia Universidad Católica de Valparaíso
dc.relation	10.1016/j.ejbt.2015.03.009
dc.rights	info:eu-repo/semantics/openAccess
dc.source	Electronic Journal of Biotechnology v.18 n.3 2015
dc.subject	Gene expression
dc.subject	Goat
dc.subject	Liver
dc.subject	Omega-3 fatty acid
dc.subject	PPAR
dc.title	Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats

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Diet high in &#945;-linolenic acid up-regulate PPAR-&#945; gene expression in the liver of goats

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Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats