The aim of this paper is to analyze and to discuss the influence of the human capital and the intellectual capital in the formation of productive cooperative networks and regional clusters. Therefore, it is made a discussion about the qualification and the knowledge in the perspective of the industrial agglomerations, developing concepts as abilities and competences, organizational learning, generation and diffusion of knowledge in enterprises’ networks. Methodologically, the work is based in a multidisciplinary bibliographical research, involving the areas of productions engineering, business administration, economy, education and sociology.En las crecientes economías del mundo globalizado, una variedad de factores definen al mercado y el contexto regulatorio para la comercialización de innovaciones estratégicas que proveen ventajas competitivas significantes a corto y largo plazo. En éste estudio se examinan como la generación de mapas tecnológicos integran estos factores contextuales con las capacidades organizacionales y los recursos de la compañía para comercializar las innovaciones estratégicas. El estudio se realizó examinando 4 casos de mapas tecnológicos: (1) Motorota, (2) Laboratorios Nacionales Sandia, (3) Los mapas Internacionales para Semiconductores y (4) Nanotecnologías. Un procedimiento consistente en 5 etapas es propuesto para la comercialización de innovaciones estratégicas. Finalmente se discuten, las implicaciones de gestión y el desarrollo de un futuro tema de investigación.In the increasingly globalized world economies, a variety of drivers define the market and regulatory contexts for commercializing the strategic innovations that provide significant competitive advantage in the near-term and long-term future. In this study we examine how technological roadmapping integrates these strategic contextual factors with the organizational capabilities and resources of the firm to commercialize strategic innovations. This is done by first examining four roadmapping case-studies: (1) at Motorola, (2) at Sandia National laboratories, (3) the National and International Roadmaps for Semiconductors, and (3) nanotechnologies. A five stage process is proposed for commercializing strategic innovations. Finally, managerial implications and potential future research are discussed.