In the last years, studies and modifications to the science and technology regulatory framework in Mexico show the increase in the attention to transfer the research results of professors and researchers from higher education institutions, towards the productive sector with the purpose of generating regional, national and international growth and development. This study has conducted to the search of the factors that determine the increase of linkage activities and technology transfer. Based on the literature review, this study develops a framework integrated with the factors considered that have a significantly impact in the university-industry linkage and technology transfer. The proposed independent variables are the following: Institutional Factors, Academic Profile, and Innovation.