This article seeks to analyze a number of factors which may influence de process of technology transfer from technological institutes to enterprises. Taking as a reference a literature review and adding up our own knowledge regarding the subject, we have developed a model of technology transfer. This model has been applied to two samples of Spanish and Brazilian technological institutes. The main objective lies in identifying those factors that may have a greater influence on the scientific and financial success of those institutes. It has been carried out a thorough data analysis with the assistance of statistical tools such as: Bivariate Correlation Analysis, Multivariate Analysis and Multiple Regression Stepwise Method. The results show some similarities as well as differences when comparing the two samples. Our results clearly indicate that the Spanish institutes exhibit a greater experience and especialization on cooperative research with comercial companies. However, even within the same country there are different patterns of especialization: some institutes focus on their own research and others seek to satisfy the needs of companies.Este artículo analiza una serie de factores que afectan al éxito en la función de transferencia tecnológica desde los institutos especializados al sector empresarial. Teniendo como base la literatura existente y añadiendo conocimientos propios, hemos construido un modelo de Transferencia y Comercialización de Tecnología. El modelo fue aplicado a una muestra de ITs brasileños y españoles y la información obtenida fue tratada con el objetivo de identificar los factores que tienen una mayor influencia en el éxito financiero y científico. Fue realizado un riguroso análisis de los datos a través de instrumentos estadísticos como: Análisis de Correlación Bivariada; Análisis Multivariante; y el Método Stepwise de Regresión Múltiple. Los resultados obtenidos muestran similitudes y diferencias al comparar las dos muestras analizadas. De entrada, se demuestra claramente la mayor experiencia relativa y especialización de los ITs Españoles en investigación cooperativa con las empresas. Pero dentro del mismo país podemos identificar diferentes formas de actuación: unos institutos con mayor vocación científica y otros fundamentalmente direccionados a atender las necesidades de las empresas.This article seeks to analyze a number of factors which may influence de process of technology transfer from technological institutes to enterprises. Taking as a reference a literature review and adding up our own knowledge regarding the subject, we have developed a model of technology transfer. This model has been applied to two samples of Spanish and Brazilian technological institutes. The main objective lies in identifying those factors that may have a greater influence on the scientific and financial success of those institutes. It has been carried out a thorough data analysis with the assistance of statistical tools such as: Bivariate Correlation Analysis, Multivariate Analysis and Multiple Regression Stepwise Method. The results show some similarities as well as differences when comparing the two samples. Our results clearly indicate that the Spanish institutes exhibit a greater experience and especialization on cooperative research with comercial companies. However, even within the same country there are different patterns of especialization: some institutes focus on their own research and others seek to satisfy the needs of companies.