The general objective of this research was to identify the unique organizational competences of Brazilian Technological Innovation Centers (TICs). We developed a theoretical framework that deals with technological innovation centers and unique organizational competences. Empirical research consisted of two sequential phases, the first qualitative and the second quantitative. The qualitative phase consisted of semi-structured interviews that were chosen through non-probabilistic selection criteria. The quantitative phase made use of a survey questionnaire that was mailed to individuals responsible for the TICs participating in the National Forum of Managers of Innovation and Technology Transfer and the Intellectual Property Network of the State of Minas Gerais. The unique organizational competences encountered were: intellectual property; national patenting; consulting services rendered by individual professors or researchers; identification of the areas of excellence in research of scientific and technological institutions via the number of registered patents, the number of scientific publications, declared lines of research, and the presence of related research groups.