Having recognized the importance of designing Science, Technology and Innovation policies (STIP), many Less Developed Countries (LDCs) such as Iran have nowadays attempt to reshape their STI policies. The policy makers of LDCs like Iran can adopt and design suitable strategies learning from the successful experiences of prosperous nations. This paper performs a comparative analysis of STI policies of some successful countries in managing their technological change. This is mostly due to the fact that the other LDCs can draw valuable lessons from these success stories which in turn can also contribute to success in their own short and long term development. Firstly, the empirical experiences of some successful nations namely (Brazil, India, China, South Africa and South Korea) will be studied. The empirical experience in STI policymaking will be surveyed. The most critical success factors contributed mostly to their management of STI policies will also be compared. Finally, a general framework of STI policymaking drawing from the experiences of these countries will be proposed for other LDCs like Iran.