This article introduces RFID technology and the EPC Network and investigates their potential for B-to-B eCommerce supply chain management. Based on empirical data gathered from four tightly interrelated firms from three layers of a supply chain, several scenarios integrating RFID and the EPC Network have been tested and evaluated. In the context of warehousing activities in one specific retail supply chain, the results indicate that i) the business process approach seems quite appropriate to capture the real potential of RFID and the EPC Network; ii) RFID technology and the EPC Network can improve the “shipping” and the “receiving” processes; iii) they can automatically trigger some business processes; iv) they foster a higher level of information sharing between supply chain members; and v) they promote the emergence of new business processes such as “process-to-process,” “process-to-machine,” and “machine-to-machine.” The paper helps to improve our understanding of the real potential of RFID and the EPC Network for business processes.Este artículo introduce a los conceptos de la tecnología RFID y las redes EPC, e investiga su potencial para la gestión de cadenas de proveedores en el comercio electrónico B-a-B. basado en datos empíricos recolectados desde compañías estrechamente relacionadas que provienen de tres distintas capas de una cadena de proveedores. En el contexto de las actividades de actividades de almacenamiento en una cadena de proveedores específica de retail, los resultados indican que (i) la aproximación al proceso de negocio se ve muy apropiado para capturar el real potencial de la RFID y la red EPC; (ii) La tecnología RFID y las redes EPC pueden mejorar los procesos de “envío” y “recepción”; (iii) pueden automáticamente gatillar algunos procesos de negocios; (iV) impulsan un nivel más alto de repartición entre los miembros de la cadena de abastecimiento; y (v) promueven el surgimiento de nuevos procesos de negocios tales como “proceso-a-proceso”, “ proceso-a-máquina”, y “máquina-a-máquina”. Este artículo ayuda a mejorar nuestro entendimiento del potencial real de la tecnología RFID y las redes EPC para los procesos de negocio.This article introduces RFID technology and the EPC Network and investigates their potential for B-to-B eCommerce supply chain management. Based on empirical data gathered from four tightly interrelated firms from three layers of a supply chain, several scenarios integrating RFID and the EPC Network have been tested and evaluated. In the context of warehousing activities in one specific retail supply chain, the results indicate that i) the business process approach seems quite appropriate to capture the real potential of RFID and the EPC Network; ii) RFID technology and the EPC Network can improve the “shipping” and the “receiving” processes; iii) they can automatically trigger some business processes; iv) they foster a higher level of information sharing between supply chain members; and v) they promote the emergence of new business processes such as “process-to-process,” “process-to-machine,” and “machine-to-machine.” The paper helps to improve our understanding of the real potential of RFID and the EPC Network for business processes.