Resumen. Las rocas volcanicas mesozoicas y cenozoicas de Chile central, excepto las del reciente, han sido afectadas por episodios de alteracion regional. Las asociaciones mineralogicas secundarias son, en general, metaestables y comprenden las siguientes facies diageneticas a metamorficas: ceolita (subfacies de mordenita, laumontita y wairakita), prehnita-pumpellyita, pumpellyita-actinolita y esquistos verdes. Abstract. The Mesozoic and Cenozoic volcanic rocks of central Chile, except recent ones, have been affected by episodes of regional alteration. The alteration, which is characterized by low-grade metastable mineral associations, comprises the following diagenetic to metamorphic facies: zeolite (mordenite, laumonlite and wairakite subfacies), prehnite-pumpellyite, pumpellyite-actinolite and greenschist.