J.S. Castillo, and M.C. García. 2013. Analysis of international competitive positioning of quality wine from Spain. Cien. Inv. Agr. 40(3): 491-501. The global vitiviniculture sector is undergoing systemic and thorough changes. Spain occupies a privileged position in the global industry, ranking first in surface area, third in production and second in export volume. In recent years, domestic consumption has experienced a clear and pronounced decline, as observed in France and Italy. Therefore, exportation has become the main commercial avenue for table and quality wine. In Spain, designated quality wine represents 50% of total production and has experienced commercial dynamics in international markets that differ from those affecting table wine. The object of this paper is to analyze the factors influencing the competitiveness of quality wine, represented by designations of origin, in international markets. After defining a competitiveness index, adapted from the Balassa index, and using environmental and internal variables, three panel data models of the most representative Designations were specified for the 2000/2001 to 2009/2010 seasons. The results demonstrated that environmental variables were more influential in explaining the weak international competitive positioning of the poorer performing Designations. European regulations resulting from the Common Agricultural Policy (CAP) and the economic crisis were significant and influential in this respect. Economies of scale, quality, and unit cost were the most influential internal factors for each D.O. factors for the most competitive quality-wine production areas.