Yellow passion fruit, because it is sensitive to the salinity of irrigation water or soil, requires restrictive water management strategies and inputs that mitigate the effects of salts on plants irrigated with harmful saline water levels. As such, an experiment was designed to evaluate the effects of bovine biofertilizer and mineral fertilization with NPK on the growth and production of yellow passion fruit plants irrigated with moderately saline water. Treatments were arranged in a randomized block with three replications and 12 plants per plot using a 4×2 factorial design with four doses of bovine biofertilizer diluted in water at 0, 33.3, 66.6 and 100% proportions in soil with and without NPK. The evaluated variables included the stem diameter, number of productive branches at the beginning of flowering (160 days after transplanting seedlings), number of fruits per hectare, average fruit weight and productivity. Biofertilizer applied at the maximum dose combined with mineral fertilization with NPK resulted in a greater growth in the stem diameter and an increased plant productivity. The 100% biofertilizer dose provided the best results. Even in treatments without mineral fertilizer, the biofertilizer increased productivity to values approaching 24 t ha-1 at the 60.65% level.