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dc.creatorGonzález C,Jorge
dc.date2000-10-01
dc.date.accessioned2019-09-10T12:39:36Z
dc.date.available2019-09-10T12:39:36Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000012
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/105308
dc.descriptionCells respond to environmental or cellular changes, rapidly switching protein activities from one state to another. In eukaryotes, a way to achieve these changes is through protein phosphorylation cycles, involving independent protein kinase and protein phosphatase activities. Current evidences show that phosphatases and kinases are also involved in the molecular basis of immune response and in diseases such as diabetes obesity and Alzheimer. In protozoan parasites like Trypanosoma and Leishmania, several kinases and phosphatases have been identified, many of them have been cloned but in several cases their biological role remains undetermined. In this review, the state-of-the art is summarized and the role of phosphatases and kinases in biological phenomena such as remodeling, invasion and pathogenic capacity of protozoan parasites is described. The real chance to use these components of signal transduction pathways as target for chemotherapeutic intervention is also discussed (Rev Méd Chile 2000; 128: 1150-60).
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98872000001000012
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.128 n.10 2000
dc.subjectLeishmania
dc.subjectPhosphorylation
dc.subjectPhosphorylase kinase
dc.subjectPhosphorylase phosphatase
dc.subjectProtozoan infections
dc.subjectTrypanosoma
dc.titleFosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas


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