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dc.creatorVinagre del P,Claudia
dc.creatorMartínez G,María José
dc.creatorVogel G,Marlene
dc.creatorTraipe C,Leonidas
dc.creatorStoppel O,Juan
dc.creatorSquella G,Olympia
dc.creatorSrur A,Miguel
dc.creatorCharlín E,Raimundo
dc.date2001-03-01
dc.date.accessioned2019-09-10T12:40:08Z
dc.date.available2019-09-10T12:40:08Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300004
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/105656
dc.descriptionBackground: Herpes simplex virus (HSV) infection of the cornea is a leading cause of blindness in occidental countries and a common recurrent manifestation of it is the immune stromal keratitis (ISK). However, it is not known whether active viral replication occurs during the acute phase of the disease, because isolation of the virus by conventional culture techniques has not been accomplished. Aim: To establish the presence of HSV in patients with ISK. Material and methods: Fourteen corneal swabbing samples, from active diseased eyes of patients with clinical diagnosis of ISK, were submitted to Herpchek® and PCR for the identification of HSV antigens and genome. Results: All ISK samples were negative by both techniques. Conclusions: It was not possible to identify HSV antigens nor their genome by the methodology used. It is likely that, they can t be detected in corneal superficial layers or probably there is no viral replication at this stage of the disease, so antiviral therapy should be reconsidered. (Rev Méd Chile 2001; 129: 259-63).
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98872001000300004
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.129 n.3 2001
dc.subjectCorneal diseases
dc.subjectKeratitis
dc.subjectKeratitis herpetic
dc.subjectHerpes simplex
dc.titleRol del virus Herpes simplex en la queratitis inmune estromal


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