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dc.creatorALVAREZ,JAIME
dc.date2001-01-01
dc.date.accessioned2019-09-10T12:40:47Z
dc.date.available2019-09-10T12:40:47Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200014
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/106058
dc.descriptionIn the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The 'autonomous axon' proposed here negates in turn transport of proteins, and asserts (i) local synthesis of axoplasmic proteins, corner stone of this model, (ii) existence of internal programs in axon and terminals, (iii) external control of programs resulting in local regulation of phenotype of axons and terminals, hence they are autonomous from perikarya; (iv) participation of perikarya through the fast transport in setting up the axonal programs but not in their immediate regulation. The word merotrophism (meros meaning part) denotes post-transcriptional regulation of phenotype of restricted regions of a cell. We surmise that merotrophism is at the base of many plastic phenomena.
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602001000200014
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.34 n.2 2001
dc.subjectplasticity
dc.subjectregeneration
dc.subjectSchwann cell
dc.subjectslow transport
dc.subjectsprouting
dc.subjecttrophism
dc.subjectWld s
dc.titleThe autonomous axon: a model based on local synthesis of proteins


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