| dc.creator | CUENCA,JIMENA | |
| dc.creator | PÉREZ,CLAUDIO A. | |
| dc.creator | AGUIRRE,ADAM J. | |
| dc.creator | SCHIATTINO,IRENE | |
| dc.creator | AGUILLÓN,J. CARLOS | |
| dc.date | 2001-01-01 | |
| dc.date.accessioned | 2019-09-10T12:41:16Z | |
| dc.date.available | 2019-09-10T12:41:16Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/106364 | |
| dc.description | Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602001000300011 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.34 n.3-4 2001 | |
| dc.title | Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population | |
