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RISK FACTORS FOR THE DEVELOPMENT OF LUNG CANCER IN A COHORT OF ADULT SMOKERS

Predictores clínicos y funcionales del riesgo de cáncer pulmonar en el seguimiento de una cohorte de adultos fumadores

dc.contributoren-US
dc.contributorFuente de financiamiento: Proyecto Fondecyt 1080671.es-ES
dc.creatorSaldías Peñafiel, Fernando; Neumotisiología Medicina PUC
dc.creatorElola Aránguiz, José Manuel; Pontificia Universidad Católica de Chile
dc.creatorUribe Monasterio, Javier; Pontificia Universidad Católica de Chile
dc.creatorMorales Soto, Arturo; Pontificia Universidad Católica de Chile
dc.creatorDíaz Patiño, Orlando; Pontificia Universidad Católica de Chile
dc.date2016-11-18
dc.date.accessioned2019-11-11T18:26:18Z
dc.date.available2019-11-11T18:26:18Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5107
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110614
dc.descriptionBackground: Identifying risk factors for lung cancer in the population could improve the cost-effectiveness of early detection programs using thoracic computed tomography (CT). Aim: To examine the risk factors of lung cancer in a cohort of adult smokers. Patients and Methods: An annual clinical and respiratory functional assessment, chest computed tomography for three years and clinical follow up for five years was carried out in 270 patients aged 65±9 years, 55% males, active or former smokers of 10 or more pack-years . Results: Thirty seven percent of patients were active smokers, consuming 37±26 packs/year, 85% had comorbidities, especially chronic obstructive pulmonary disease (COPD) (66%), hypertension (48%), diabetes (22%) and dyslipidemia (42%). Thirteen percent of patients had family history of lung cancer. Twenty-one cases of lung cancer were detected in the five years follow up, especially squamous cell carcinoma and adenocarcinoma. In the univariate analysis, the main risk factors for lung cancer identified were an age older than 60 years, history of COPD, family history of lung cancer, active smoking, tobacco consumption more than 30 pack/year and lung hyperinflation. In multivariate analysis, the three independent risk factors for lung cancer were a family history of lung cancer, active smoking and the number of packs per year of tobacco consumption. Conclusions: The identification of risk groups probably will improve the performance of programs for early detection of lung cancer.en-US
dc.descriptionBackground: Identifying risk factors for lung cancer in the population could improve the cost-effectiveness of early detection programs using thoracic computed tomography (CT). Aim: To examine the risk factors of lung cancer in a cohort of adult smokers. Patients and Methods: An annual clinical and respiratory functional assessment, chest computed tomography for three years and clinical follow up for five years was carried out in 270 patients aged 65±9 years, 55% males, active or former smokers of 10 or more pack-years . Results: Thirty seven percent of patients were active smokers, consuming 37±26 packs/year, 85% had comorbidities, especially chronic obstructive pulmonary disease (COPD) (66%), hypertension (48%), diabetes (22%) and dyslipidemia (42%). Thirteen percent of patients had family history of lung cancer. Twenty-one cases of lung cancer were detected in the five years follow up, especially squamous cell carcinoma and adenocarcinoma. In the univariate analysis, the main risk factors for lung cancer identified were an age older than 60 years, history of COPD, family history of lung cancer, active smoking, tobacco consumption more than 30 pack/year and lung hyperinflation. In multivariate analysis, the three independent risk factors for lung cancer were a family history of lung cancer, active smoking and the number of packs per year of tobacco consumption. Conclusions: The identification of risk groups probably will improve the performance of programs for early detection of lung cancer.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5107/2576
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/23874
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/23872
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/23870
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/23873
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/23871
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/23869
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/24010
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5107/25224
dc.sourceRevista Médica de Chile; Vol. 144, núm. 11 (2016): NOVIEMBRE 2016es-ES
dc.source0034-9887
dc.subjectEarly Detective of Cancer; Early Diagnosis; Lung Cancer; Risk Factors; Tobacco Smokingen-US
dc.subjectEarly Detective of Cancer; Early Diagnosis; Lung Cancer; Risk Factors; Tobacco Smokinges-ES
dc.titleRISK FACTORS FOR THE DEVELOPMENT OF LUNG CANCER IN A COHORT OF ADULT SMOKERSen-US
dc.titlePredictores clínicos y funcionales del riesgo de cáncer pulmonar en el seguimiento de una cohorte de adultos fumadoreses-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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