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EVOLUTION OF MORTALITY, RETENTION AND LOSS TO FOLLOW UP OF HIV INFECTED SUBJECTS FOLLOWED IN A SPECIAL CLINIC

Evolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infeccion por VIH: Fundación Arriarán 1990-2015.

dc.contributoren-US
dc.contributores-ES
dc.creatorCortés, Claudia P; Facultad de Medicina Universidad de Chile Fundación Arriarán.
dc.creatorLizana, Danae; Hospital Clinico San Borja Arriaran Fundacion Arriaran
dc.creatorNorthland, Rebeca; Facultad de Medicina Universidad de Chile Fundación Arriarán.
dc.creatorWolff R, Marcelo; Facultad de Medicina Universidad de Chile Fundación Arriarán.
dc.date2018-03-22
dc.date.accessioned2019-11-11T18:26:30Z
dc.date.available2019-11-11T18:26:30Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6204
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110688
dc.descriptionBackground: The HIV epidemic reached Chile in late 1980s and as an early response, AIDS care centers were organized. Fundación Arriarán (FA) was the first center. Free antiretroviral therapy (ART) was later provided with progressive coverage and complexity over the years. Aim: To quantify evolution of mortality, retention and loss to follow up (LTFU) over 25 years according to different periods of access to ART, from no availability to full coverage with current drugs at FA center. Material and methods: Retrospective analysis of FA database of 5.080 adults admitted between 1990 and 2014. The sample was distributed in 7 groups: A: no ART (1990-92), B: monotherapy, C: dual therapy, D: dual/triple ART, E: early triple therapy with incomplete coverage, F same as E but with complete coverage and G: contemporary ART (2008-14). Mortality, retention and LTFU were evaluated at 1, 3, 5, 7 and 10 years and at 31/12/2015. Results: Mortality varied from 40% to 2%, and 62% to 7% at 1 and 5 years, for groups A and G respectively; from 71% to 16% at 10 years for groups A and E, respectively. Retention at 5 years were 28%, 23%, 39%, 62%, 75%, 75% and 77 % for groups A to G, respectively. LTFU was 10%, 19%, 15%, 17%, 9% 12% and 10% at 5 years for same groups, respectively. At 12/31/2015 22% of patients had died, 11% were LTFU, 60% were retained in care and 6% had been transferred. Conclusions: There is a marked reduction in mortality and increase in retention of HIV patients’ concomitant to expanded access to modern therapy, although LTFU remains a problem.en-US
dc.descriptionBackground: The HIV epidemic reached Chile in late 1980s and as an early response, AIDS care centers were organized. Fundación Arriarán (FA) was the first center. Free antiretroviral therapy (ART) was later provided with progressive coverage and complexity over the years. Aim: To quantify evolution of mortality, retention and loss to follow up (LTFU) over 25 years according to different periods of access to ART, from no availability to full coverage with current drugs at FA center. Material and methods: Retrospective analysis of FA database of 5.080 adults admitted between 1990 and 2014. The sample was distributed in 7 groups: A: no ART (1990-92), B: monotherapy, C: dual therapy, D: dual/triple ART, E: early triple therapy with incomplete coverage, F same as E but with complete coverage and G: contemporary ART (2008-14). Mortality, retention and LTFU were evaluated at 1, 3, 5, 7 and 10 years and at 31/12/2015. Results: Mortality varied from 40% to 2%, and 62% to 7% at 1 and 5 years, for groups A and G respectively; from 71% to 16% at 10 years for groups A and E, respectively. Retention at 5 years were 28%, 23%, 39%, 62%, 75%, 75% and 77 % for groups A to G, respectively. LTFU was 10%, 19%, 15%, 17%, 9% 12% and 10% at 5 years for same groups, respectively. At 12/31/2015 22% of patients had died, 11% were LTFU, 60% were retained in care and 6% had been transferred. Conclusions: There is a marked reduction in mortality and increase in retention of HIV patients’ concomitant to expanded access to modern therapy, although LTFU remains a problem.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6204/3842
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6204/31052
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6204/31057
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6204/33014
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6204/33045
dc.sourceRevista Médica de Chile; Vol. 146, núm. 3 (2018): MARZO 2018es-ES
dc.source0034-9887
dc.subjectCohort Studies; HIV; Lost to Follow-Up; Mortality; Survivalen-US
dc.subjectCohort Studies; HIV; Lost to Follow-Up; Mortality; Survivales-ES
dc.titleEVOLUTION OF MORTALITY, RETENTION AND LOSS TO FOLLOW UP OF HIV INFECTED SUBJECTS FOLLOWED IN A SPECIAL CLINICen-US
dc.titleEvolución de mortalidad, abandono, traslado y retención a corto, mediano y largo plazo en pacientes con infeccion por VIH: Fundación Arriarán 1990-2015.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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