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Evaluación de la anticoagulación con Rivaroxaban, en pacientes con fibrilación auricular no valvular de reciente diagnóstico.

dc.contributoren-US
dc.contributorFondos de Dirección de Investigación Pontificia Universidad Católica, concurso de becas de investigación para médicos residentes de post-grado, proyecto BS 11/13. Fondos de la División de Enfermedades Cardiovasculares UCes-ES
dc.creatorNeira, Victor; Departamento de Enfermedades Cardiovasculares Pontificia Universidad Católica de Chile
dc.creatorCorbalán, Ramón; Departamento de Enfermedades Cardiovasculares Pontificia Universidad Católica de Chile
dc.creatorPereira, Jaime; Departamento de Hematología y Oncología, Pontificia Universidad Católica de Chile
dc.creatorPanes, Olga; Departamento de Hematología y Oncología, Pontificia Universidad Católica de Chile
dc.creatorGarayar, Bernardita; Departamento de Enfermedades Cardiovasculares Pontificia Universidad Católica de Chile
dc.creatorAizman, Andrés; Departamento de Enfermedades Cardiovasculares Pontificia Universidad Católica de Chile
dc.creatorLlevaneras, Silva; Departamento de Enfermedades Cardiovasculares Pontificia Universidad Católica de Chile
dc.creatorVillarroel, Luis; Departamento de Salud Pública Pontificia Universidad Católica de Chile
dc.date2016-09-13
dc.date.accessioned2019-11-11T18:26:35Z
dc.date.available2019-11-11T18:26:35Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4939
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110754
dc.descriptionBackground: Atrial fibrillation (AF) generates a hypercoagulable state with an increased thrombin generation and raised levels of thrombin-antithrombin complexes, which results in a high risk of stroke and thromboembolism. Aim: To evaluate the anticoagulant effect of Rivaroxaban by anti-Xa factor activity and its correlation with thrombin-antithrombin complexes, thrombin generation and prothrombin time in patients newly diagnosed with non-valvular AF. Patients and methods: Prospective study in patients with indication of anticoagulation. Demographic variables, cardiovascular risk factors, CHA2DS2VASc and HAS-BLED scores were recorded. Blood samples were taken at baseline, at 3 and 24 hours after the administration of the drug and at 30 days. Rivaroxaban levels, anti-Xa activity, prothrombin time, thrombin generation and plasma levels of thrombin-antithrombin complexes were determined. Results: We studied 20 patients aged 76.3 ± 8.0 years (60% female) with a CHA2DS2VASc score >2 points. The anti-Xa factor activity correlated with Rivaroxaban plasma levels at 3 hours (r=0.61, pen-US
dc.descriptionBackground: Atrial fibrillation (AF) generates a hypercoagulable state with an increased thrombin generation and raised levels of thrombin-antithrombin complexes, which results in a high risk of stroke and thromboembolism. Aim: To evaluate the anticoagulant effect of Rivaroxaban by anti-Xa factor activity and its correlation with thrombin-antithrombin complexes, thrombin generation and prothrombin time in patients newly diagnosed with non-valvular AF. Patients and methods: Prospective study in patients with indication of anticoagulation. Demographic variables, cardiovascular risk factors, CHA2DS2VASc and HAS-BLED scores were recorded. Blood samples were taken at baseline, at 3 and 24 hours after the administration of the drug and at 30 days. Rivaroxaban levels, anti-Xa activity, prothrombin time, thrombin generation and plasma levels of thrombin-antithrombin complexes were determined. Results: We studied 20 patients aged 76.3 ± 8.0 years (60% female) with a CHA2DS2VASc score >2 points. The anti-Xa factor activity correlated with Rivaroxaban plasma levels at 3 hours (r=0.61, pes-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 144, núm. 9 (2016): SEPTIEMBRE 2016es-ES
dc.source0034-9887
dc.subjectAtrial Fibrillation; Rivaroxaban; Thrombin; Thrombin Timeen-US
dc.subjectAtrial Fibrillation; Rivaroxaban; Thrombin; Thrombin Timees-ES
dc.titleEVALUATION OF ORAL ANTICOAGULATION WITH RIVAROXABAN, IN PATIENTS WITH NEW ONSET NON VALVULAR ATRIAL FIBRILLATIONen-US
dc.titleEvaluación de la anticoagulación con Rivaroxaban, en pacientes con fibrilación auricular no valvular de reciente diagnóstico.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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