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INSULIN AUTOIMMUNE SYNDROME. REPORT OF TWO CASES

Síndrome de hipoglicemia autoinmune. Primeros casos en Chile.

dc.contributoren-US
dc.contributores-ES
dc.creatorLanas, Alejandra; Hospital Clínico de la Universidad de Chile
dc.creatorParedes, Ana; Hospital Regional de Copiapó
dc.creatorEspinosa, Consuelo; Clínica Alemana Hospital Clínico de la Universidad de Chile
dc.creatorCaamaño, Egardo; Hospital Clínico de la Universidad de Chile
dc.creatorPérez-Bravo, Francisco; Laboratorio de Nutrigenómica, Departamento de Nutrición, Facultad de Medicina, Universidad de Chile
dc.creatorPinto, Rodrigo; Hospital Clínico de la Universidad de Chile
dc.creatorIñiguez, Germán; IDIMI Universidad de Chile
dc.creatorMartínez, Darío; Hospital San Borja-Arriarán, Unidad de Hemodinamia
dc.creatorSoto, Néstor; Hospital San Borja-Arriarán Unidad de Endocrinología y Diabetes
dc.date2015-07-10
dc.date.accessioned2019-11-11T18:26:35Z
dc.date.available2019-11-11T18:26:35Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4181
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110756
dc.descriptionInsulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia with extremely high insulin levels and the presence of circulating autoantibodies against insulin, in patients who have never been exposed to exogenous insulin. We report two patients with the syndrome. A 36 years old male presenting with hypoglycemia in the emergency room had an oral glucose tolerance test showed basal and 120 min glucose levels of 88 and 185 mg/dl. The basal and 120 min insulin levels were 2759 and 5942 ?UI/ml. The presence of an insulin secreting tumor was discarded. Anti-insulin antibodies were positive. He was successfully treated with a diet restricted in carbohydrates and frequent meals in small quantities. A 65 years old female presenting with hypoglycemia in the emergency room had the fasting insulin levels of 1910 µUI/ml. No insulin secreting tumor was detected by images and anti-insulin antibodies were positive. The polyethylene glycol precipitation test showed a basal and after exposition insulin level 1483 and 114 µUI/ml, respectively. She responded partially to diet and acarbose and required the use of prednisone with a good clinical response.en-US
dc.descriptionInsulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia with extremely high insulin levels and the presence of circulating autoantibodies against insulin, in patients who have never been exposed to exogenous insulin. We report two patients with the syndrome. A 36 years old male presenting with hypoglycemia in the emergency room had an oral glucose tolerance test showed basal and 120 min glucose levels of 88 and 185 mg/dl. The basal and 120 min insulin levels were 2759 and 5942 ?UI/ml. The presence of an insulin secreting tumor was discarded. Anti-insulin antibodies were positive. He was successfully treated with a diet restricted in carbohydrates and frequent meals in small quantities. A 65 years old female presenting with hypoglycemia in the emergency room had the fasting insulin levels of 1910 µUI/ml. No insulin secreting tumor was detected by images and anti-insulin antibodies were positive. The polyethylene glycol precipitation test showed a basal and after exposition insulin level 1483 and 114 µUI/ml, respectively. She responded partially to diet and acarbose and required the use of prednisone with a good clinical response.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 143, núm. 7 (2015): JULIO 2015es-ES
dc.source0034-9887
dc.subjectAutoimmune response; Hypoglycemia; Insulin antibodiesen-US
dc.subjectAutoimmune response; Hypoglycemia; Insulin antibodieses-ES
dc.titleINSULIN AUTOIMMUNE SYNDROME. REPORT OF TWO CASESen-US
dc.titleSíndrome de hipoglicemia autoinmune. Primeros casos en Chile.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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