Entendiendo las terapias actuales en melanoma metastásico

UNDERSTANDING CURRENT THERAPIES IN METASTATIC MELANOMA

Author
Rodríguez, Rocío; Pontificia Universidad Católica de Chile

Parra, Angela; Pontificia Universidad Católica de Chile

González, Sergio; Pontificia Universidad Católica de Chile

Molgó, Montserrat; Pontificia Universidad Católica de Chile

Droppelmann, Nicolás; Pontificia Universidad Católica de Chile

Acevedo C, Francisco; Pontificia Universidad Católica de Chile

Peña, José; Pontificia Universidad Católica de Chile

Uribe, Pablo; Pontificia Universidad Católica de Chile

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4468
Abstract
Cutaneous melanoma is a highly aggressive tumor developing from melanocytes, its incidence is increasing, and prognosis in advanced stages is daunting. New therapies have been approved during the recent years with unprecedented results, including inhibitors of MAPK/ERK pathway and immune checkpoint blockade (anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) as ipilimumab, anti-programmed cell death protein 1 (PD-1) as pembrolizumab and anti-programmed cell death protein 1 ligand (PDL-1), among many others). The aim of this paper is to review currently available metastatic melanoma therapies focusing mainly on new therapies that have demonstrated effectiveness, after several decades of little progress in the treatment of this disease.
 
Cutaneous melanoma is a highly aggressive tumor developing from melanocytes, its incidence is increasing, and prognosis in advanced stages is daunting. New therapies have been approved during the recent years with unprecedented results, including inhibitors of MAPK/ERK pathway and immune checkpoint blockade (anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) as ipilimumab, anti-programmed cell death protein 1 (PD-1) as pembrolizumab and anti-programmed cell death protein 1 ligand (PDL-1), among many others). The aim of this paper is to review currently available metastatic melanoma therapies focusing mainly on new therapies that have demonstrated effectiveness, after several decades of little progress in the treatment of this disease.
 
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