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SERUM C-REACTIVE PROTEIN AS PROGNOSTIC IN IMMUNOCOMPETENT ADULTS HOSPITALIZED FOR A COMMUNITY-ACQUIRED PNEUMONIA.

Utilidad de la proteína C reactiva sérica en el diagnóstico y tratamiento del adulto inmunocompetente hospitalizado por neumonía adquirida en la comunidad.

dc.contributoren-US
dc.contributores-ES
dc.creatorSaldías Peñafiel, Fernando; Facultad de Medicina, P. Universidad Católica de Chile.
dc.creatorSalinas Rossel, Gerardo; Facultad de Medicina, Universidad de Chile.
dc.creatorFarcas Oksenberg, Katia; Facultad de Medicina, P. Universidad Católica de Chile.
dc.creatorReyes Sánchez, Antonia; Facultad de Medicina, P. Universidad Católica de Chile.
dc.creatorDíaz Patiño, Orlando; Facultad de Medicina, P. Universidad Católica de Chile.
dc.date2019-08-08
dc.date.accessioned2019-11-11T18:26:49Z
dc.date.available2019-11-11T18:26:49Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/7409
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110863
dc.descriptionBackground: C-reactive protein (CRP) is used to monitor patients’ response during treatment of infectious diseases. Morbidity and mortality associated with community-acquired pneumonia (CAP) is high, particularly in hospitalized patients. Better risk prediction during hospitalization could improve management and ultimately reduce mortality rates. Aim: To evaluate CRP measured at admission and the third day of hospitalization as a predictor for adverse events in CAP. Material and methods: A prospective cohort study of adult patients hospitalized with CAP at an academic hospital. Major adverse outcomes were admission to ICU, mechanical ventilation, prolonged hospital length of stay, hospital complications and 30-day mortality. Predictive associations between CRP (as absolute levels and relative decline at third day) and adverse events were analyzed. Results: Eight hundred and twenty-three patients were assessed, 19% were admitted to ICU and 10.6% required mechanical ventilation. The average hospital stay was 8.8 ± 8.2 days, 42% had nosocomial complications and 8.1% died within 30 days. Ninety eight percent of patients had elevated serum CRP on admission to the hospital (18.1±14.1 mg/dL). C-reactive protein measured at admission was associated with the risk of bacterial pneumonia, bacteremic pneumonia, septic shock and use of mechanical ventilation. Lack of CRP decline within three days of hospitalization was associated with high risk of complications, septic shock, mechanical ventilation and prolonged hospital stay. Conclusions: CRP responses at third day of hospital admission was a valuable predictor of adverse events in hospitalized CAP adult patients.en-US
dc.descriptionBackground: C-reactive protein (CRP) is used to monitor patients’ response during treatment of infectious diseases. Morbidity and mortality associated with community-acquired pneumonia (CAP) is high, particularly in hospitalized patients. Better risk prediction during hospitalization could improve management and ultimately reduce mortality rates. Aim: To evaluate CRP measured at admission and the third day of hospitalization as a predictor for adverse events in CAP. Material and methods: A prospective cohort study of adult patients hospitalized with CAP at an academic hospital. Major adverse outcomes were admission to ICU, mechanical ventilation, prolonged hospital length of stay, hospital complications and 30-day mortality. Predictive associations between CRP (as absolute levels and relative decline at third day) and adverse events were analyzed. Results: Eight hundred and twenty-three patients were assessed, 19% were admitted to ICU and 10.6% required mechanical ventilation. The average hospital stay was 8.8 ± 8.2 days, 42% had nosocomial complications and 8.1% died within 30 days. Ninety eight percent of patients had elevated serum CRP on admission to the hospital (18.1±14.1 mg/dL). C-reactive protein measured at admission was associated with the risk of bacterial pneumonia, bacteremic pneumonia, septic shock and use of mechanical ventilation. Lack of CRP decline within three days of hospitalization was associated with high risk of complications, septic shock, mechanical ventilation and prolonged hospital stay. Conclusions: CRP responses at third day of hospital admission was a valuable predictor of adverse events in hospitalized CAP adult patients.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/7409/5159
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/7409/39540
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/7409/39869
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/7409/39872
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/7409/41182
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/7409/41183
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/7409/41184
dc.sourceRevista Médica de Chile; Vol. 147, núm. 8 (2019): AGOSTO 2019es-ES
dc.source0034-9887
dc.subjectBiomarkers; Community-Acquired Infections; C-Reactive Protein; Mortality; Pneumoniaen-US
dc.subjectBiomarkers; Community-Acquired Infections; C-Reactive Protein; Mortality; Pneumoniaes-ES
dc.titleSERUM C-REACTIVE PROTEIN AS PROGNOSTIC IN IMMUNOCOMPETENT ADULTS HOSPITALIZED FOR A COMMUNITY-ACQUIRED PNEUMONIA.en-US
dc.titleUtilidad de la proteína C reactiva sérica en el diagnóstico y tratamiento del adulto inmunocompetente hospitalizado por neumonía adquirida en la comunidad.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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