CLINICAL APPLICATIONS OF PHARMACOGENETICS

Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica

Author
Quiñones, Luis; Universidad de Chile.

Roco, Angela; 1. Ministerio de Salud. 2. Universidad de Chile 3. Universidad Andres Bello

Cayún, Juan P; Universidad de Chile

Escalante, Paula; Universidad de Chile

Miranda, Carla; Universidad de Chile

Varela, Nelson; Universidad de Chile

Meneses, Francisca; Universidad Santo Tomás

Gallegos, Bastián; Universidad Santo Tomás

Zaruma-Torres, Fausto; 1. Instituto Politécnico Nacional, Durango, México. 2. Universidad de Cuenca

Lares-Asseff, Ismael; Instituto Politécnico Nacional, Durango, México.

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5159
Abstract
Pharmacogenetics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
 
Pharmacogenetics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
 
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