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CLINICAL APPLICATIONS OF PHARMACOGENETICS

Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica

dc.contributoren-US
dc.contributorFONDECYTes-ES
dc.creatorQuiñones, Luis; Universidad de Chile.
dc.creatorRoco, Angela; 1. Ministerio de Salud. 2. Universidad de Chile 3. Universidad Andres Bello
dc.creatorCayún, Juan P; Universidad de Chile
dc.creatorEscalante, Paula; Universidad de Chile
dc.creatorMiranda, Carla; Universidad de Chile
dc.creatorVarela, Nelson; Universidad de Chile
dc.creatorMeneses, Francisca; Universidad Santo Tomás
dc.creatorGallegos, Bastián; Universidad Santo Tomás
dc.creatorZaruma-Torres, Fausto; 1. Instituto Politécnico Nacional, Durango, México. 2. Universidad de Cuenca
dc.creatorLares-Asseff, Ismael; Instituto Politécnico Nacional, Durango, México.
dc.date2017-03-13
dc.date.accessioned2019-11-11T18:26:56Z
dc.date.available2019-11-11T18:26:56Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5159
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110888
dc.descriptionPharmacogenetics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.en-US
dc.descriptionPharmacogenetics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 145, núm. 4 (2017): ABRIL 2017es-ES
dc.source0034-9887
dc.subjectPharmacogenetics; Pharmacokinetics; Pharmacogenomic variants; Polymorphisms, Geneticen-US
dc.subjectPharmacogenetics; Pharmacokinetics; Pharmacogenomic variants; Polymorphisms, Genetices-ES
dc.titleCLINICAL APPLICATIONS OF PHARMACOGENETICSen-US
dc.titleFarmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínicaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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