Show simple item record

27- HYDROXYCHOLESTEROL REVERSES ESTRADIOL INDUCED INHIBITION OF PLATELET AGGREGATION IN POSTMENOPAUSAL WOMEN

Efecto del 27-hidroxicolesterol en la acción antiplaquetaria de estradiol en mujeres postmenopáusicas

dc.contributoren-US
dc.contributorInvestigación financiada por Vicerrectoría ID, Proyecto Enlace ENL007/14 Universidad de Chilees-ES
dc.creatorRocha, Gladys; Instituto de Nutrición y Tecnología de los Alimentos Dr. Fernando Monckeberg, Universidad de Chile, Santiago, Chile
dc.creatorSierralta, Walter; Instituto de Nutrición y Tecnología de los Alimentos Dr. Fernando Monckeberg, Universidad de Chile, Santiago, Chile
dc.creatorValladares, Luis; Instituto de Nutrición y Tecnología de los Alimentos Dr. Fernando Monckeberg, Universidad de Chile, Santiago, Chile
dc.date2016-09-07
dc.date.accessioned2019-11-11T18:26:57Z
dc.date.available2019-11-11T18:26:57Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4954
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110891
dc.descriptionBackground: The decline of estrogen levels increases cardiovascular risk in women. Platelets express estrogen receptors and 17?-estradiol- (E2) can produce a protective effect on thrombus formation. The hydroxylation of cholesterol generates several sterols and 27-hydroxycholesterol (27HC) predominates in circulation. Aim: To evaluate the effect of 27HC as an endogenous antagonist of the anti-aggregating properties of E2 in platelets of postmenopausal women. Material and methods: Platelet function of postmenopausal women was evaluated ex–vivo. Platelets pre-incubated with 27HC in the presence or absence of E2, were stimulated with collagen. Aggregation was evaluated using turbidimetry using a Chrono-log aggregometer. Results: Collagen-stimulated platelet aggregation was significantly inhibited by E2. The inhibitory effect of E2 on collagen-stimulated platelet aggregation was significantly reversed in the presence of 27HC. Conclusions: The suppressive effect of E2 on platelet aggregation is inhibited by 27HC, which could contribute to increase cardiovascular risk in postmenopausal women.en-US
dc.descriptionBackground: The decline of estrogen levels increases cardiovascular risk in women. Platelets express estrogen receptors and 17?-estradiol- (E2) can produce a protective effect on thrombus formation. The hydroxylation of cholesterol generates several sterols and 27-hydroxycholesterol (27HC) predominates in circulation. Aim: To evaluate the effect of 27HC as an endogenous antagonist of the anti-aggregating properties of E2 in platelets of postmenopausal women. Material and methods: Platelet function of postmenopausal women was evaluated ex–vivo. Platelets pre-incubated with 27HC in the presence or absence of E2, were stimulated with collagen. Aggregation was evaluated using turbidimetry using a Chrono-log aggregometer. Results: Collagen-stimulated platelet aggregation was significantly inhibited by E2. The inhibitory effect of E2 on collagen-stimulated platelet aggregation was significantly reversed in the presence of 27HC. Conclusions: The suppressive effect of E2 on platelet aggregation is inhibited by 27HC, which could contribute to increase cardiovascular risk in postmenopausal women.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4954/2575
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23076
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23077
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23148
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23161
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23347
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23381
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/23396
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/25222
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4954/25223
dc.sourceRevista Médica de Chile; Vol. 144, núm. 11 (2016): NOVIEMBRE 2016es-ES
dc.source0034-9887
dc.subjectEstradiol; 27-hydroxycholesterol; Platelet Aggregation; Postmenopauseen-US
dc.subjectEstradiol; 27-hydroxycholesterol; Platelet Aggregation; Postmenopausees-ES
dc.title27- HYDROXYCHOLESTEROL REVERSES ESTRADIOL INDUCED INHIBITION OF PLATELET AGGREGATION IN POSTMENOPAUSAL WOMENen-US
dc.titleEfecto del 27-hidroxicolesterol en la acción antiplaquetaria de estradiol en mujeres postmenopáusicases-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


This item appears in the following Collection(s)

Show simple item record