Caracterización de la ingestión por sobredosis de paracetamol. Reporte de un centro de información toxicológica chileno.

Author
Bravo, Victoria; Centro de Información Toxicológica y de Medicamentos de la Pontificia Universidad Católica de Chile (CITUC). Enfermera

Román, Matías; Escuela de Medicina Pontificia Universidad Católica de Chile. Licenciado medicina UC

Bettini, Marli; Centro de Información Toxicológica y de Medicamentos de la Pontificia Universidad Católica de Chile (CITUC). Enfermera Matrona

Cerda, Patricia; Centro de Información Toxicológica y de Medicamentos de la Pontificia Universidad Católica de Chile (CITUC). Enfermera Matrona

Mieres, Juan José; Centro de Información Toxicológica y de Medicamentos de la Pontificia Universidad Católica de Chile (CITUC). d Químico Farmacéutico

Paris, Enrique; Centro de Información Toxicológica y de Medicamentos de la Pontificia Universidad Católica de Chile (CITUC). Pediatra, Director CITUC

Rios, Juan Carlos

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1586
Abstract
CHARACTERIZATION OF PARACETAMOL OVERDOSE. REPORT OF A POISON INFORMATION CENTER IN CHILE.Background: Paracetamol (acetaminophen) is an analgesic and antipyretic drug widely used across the world. Its ingestion is one of the most common causes of drug overdose.  In the United States is the first cause of acute hepatitis in adults. Aim: To describe the epidemiological profile of paracetamol overdose in Chile. Material and methods: Cross sectional retrospective study that included all the phone call inquiries received at the Poison Control Center of the Pontificia Universidad Catolica de Chile (CITUC) during 2009.   Results: Nine hundred fifty nine inquiries involving acute paracetamol exposures were received. Women represented a 63.1% of the cases. Half of the cases were suicide attempts, of which 74.8% were women. Accidental exposures occurred mainly in children. In 29.3% of the patients, the exposure was considered to involve a hepatotoxic dose. Women had 2.7 times the risk of men to ingest a toxic dose of paracetamol with suicidal purpose (Odds ratio (OR)=2.7; 95% confidence interval (CI): 2.1-3.6; p
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