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Enfermedad renal por depósito idiopático de cadenas livianas. Caso clínico.

dc.contributores-ES
dc.creatorTrimarchi, Hernán
dc.creatorLombi, Fernando
dc.creatorForrester, Mariano
dc.creatorPomeranz, Vanesa
dc.creatorRabinovich, Oscar
dc.creatorStemmelin, Germán R.
dc.creatorRuiz, Pablo A.
dc.creatorIotti, Alejandro
dc.creatorYoung, Pablo
dc.date2013-03-14
dc.date.accessioned2019-11-11T18:27:15Z
dc.date.available2019-11-11T18:27:15Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1769
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111064
dc.description      KIDNEY INVOLVEMENT IN IDIOPATHIC LIGHT CHAIN DISEASE. REPORT OF ONE CASE Idiopathic Light Chain disease (ILCD) is a systemic disease characterized by a deposit in different organs of light chain monoclonal immunoglobulins, produced by an abnormal clone of B cells. It is usually found in the course of a plasma cell dyscrasia and in other lymphoproliferative alterations; however it may occur in absence of any hematologic disease and is denominated as idiopathic. We report a 51 years old male admitted to the hospital due to anasarca. Laboratory evaluation showed a serum creatinine of 1.4 mg/dl, a serum albumin of 1.6 g/dl, a serum cholesterol of 687 mg/dl and a proteinuria of 5.3 g/day. Light chains with a predominance of a monoclonal component were identified in urinary proteins by electrophoresis and kappa chains were identified by immunofixation. A renal biopsy showed a diffuse nodular glomerulopathy with a 35% tubular atrophy and interstitial sclerosis. Electron microscopy confirmed light chain deposition. The bone marrow biopsy showed a myeloid hyperplasia. The patient was initially treated with methylprednisolone and plasmapheresis with a reduction in serum creatinine and disappearance of urinary kappa component. Albuminuria persisted and a malnutrition-inflammatory complex syndrome was diagnosed. Hemodialysis with ultrafiltration was started along with cyclophosphamide. The patient received hemodialysis for six months and continued with methylprednisolone.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1769/88
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1769/3985
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1769/4074
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1769/7289
dc.sourceRevista Médica de Chile; Vol. 141, núm. 3 (2013): MARZO 2013es-ES
dc.source0034-9887
dc.subjectImmunoglobulin Light chains; Proteinuria; Plasmapheresis; Renal dialysises-ES
dc.titleEnfermedad renal por depósito idiopático de cadenas livianas. Caso clínico.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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