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NOVEL PHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS OF LEPTIN

Nuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina

dc.contributoren-US
dc.contributorFondecyt, Conicyt-PAI, Pontificia Universidad Católica de Chilees-ES
dc.creatorGoldenberg, Denisse; Departamento de Nutrición, Diabetes y Metabolismo. Escuela de Medicina. Pontificia Universidad Católica de Chile
dc.creatorSantos, José Luis; Departamento de Nutrición, Diabetes y Metabolismo. Escuela de Medicina. Pontificia Universidad Católica de Chile
dc.creatorHodgson, María Isabel; Departamento de Nutrición, Diabetes y Metabolismo. Escuela de Medicina. Pontificia Universidad Católica de Chile
dc.creatorCortés, Víctor A; Departamento de Nutrición, Diabetes y Metabolismo. Escuela de Medicina. Pontificia Universidad Católica de Chile
dc.date2014-06-10
dc.date.accessioned2019-11-11T18:27:25Z
dc.date.available2019-11-11T18:27:25Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/2800
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111119
dc.descriptionThe adipose tissue is an endocrine organ that produces a variety of protein hormones. One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Acting at a local level, leptin modulates the immune system and promotes liver fibrogenesis. The most promising therapeutic implications of leptin will possibly be in type 1 diabetes mellitus (DM1). Its supplementation in animal models of DM1 prevents hyperglycemia and ketoacidosis. These actions depend on the activation of leptin receptors in the central nervous system and the suppression of glucagon signaling in the liver.en-US
dc.descriptionThe adipose tissue is an endocrine organ that produces a variety of protein hormones. One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Acting at a local level, leptin modulates the immune system and promotes liver fibrogenesis. The most promising therapeutic implications of leptin will possibly be in type 1 diabetes mellitus (DM1). Its supplementation in animal models of DM1 prevents hyperglycemia and ketoacidosis. These actions depend on the activation of leptin receptors in the central nervous system and the suppression of glucagon signaling in the liver.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 142, núm. 6 (2014): JUNIO 2014es-ES
dc.source0034-9887
dc.subjectDiabetes mellitus; Leptin; Lipodystrophy; Obesityen-US
dc.subjectDiabetes mellitus; Leptin; Lipodystrophy; Obesityes-ES
dc.titleNOVEL PHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS OF LEPTINen-US
dc.titleNuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptinaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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