ASSOCIATION BETWEEN MICRORNA SINGLE NUCLEOTIDE POLYMORPHISMS AND THE RISK OF HEPATOCELLULAR CARCINOMA

Association between SNPs in miRNA3152andmiRNA449b and the risk to hepatocellular carcinoma

Author
Li, Wenshuai; Fudan university

Ma, Yanyun; Fudan University

Zeng, Deqing; Fudan University

Zhang, Jun; Fudan University

Wang, Rui; Fudan University

Hu, Jingyi; Fudan University

Yang, Dongqin; Fudan University

Hu, Heping; Second Military Medical University

Wang, Juncun; Fudan University

Liu, Jie; Fudan University

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4628
Abstract
Background: Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors. Aim: To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material and methods: Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls. Results: A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele. Conclusions: This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.
 
Background: Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors. Aim: To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material and methods: Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls. Results: A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele. Conclusions: This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.
 
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