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ASSOCIATION BETWEEN MICRORNA SINGLE NUCLEOTIDE POLYMORPHISMS AND THE RISK OF HEPATOCELLULAR CARCINOMA

Association between SNPs in miRNA3152andmiRNA449b and the risk to hepatocellular carcinoma

dc.contributorthe Ministry of Science and Technology of Chinaen-US
dc.contributores-ES
dc.creatorLi, Wenshuai; Fudan university
dc.creatorMa, Yanyun; Fudan University
dc.creatorZeng, Deqing; Fudan University
dc.creatorZhang, Jun; Fudan University
dc.creatorWang, Rui; Fudan University
dc.creatorHu, Jingyi; Fudan University
dc.creatorYang, Dongqin; Fudan University
dc.creatorHu, Heping; Second Military Medical University
dc.creatorWang, Juncun; Fudan University
dc.creatorLiu, Jie; Fudan University
dc.date2016-03-30
dc.date.accessioned2019-11-11T18:27:49Z
dc.date.available2019-11-11T18:27:49Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4628
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111284
dc.descriptionBackground: Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors. Aim: To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material and methods: Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls. Results: A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele. Conclusions: This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.en-US
dc.descriptionBackground: Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors. Aim: To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material and methods: Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls. Results: A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele. Conclusions: This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.es-ES
dc.formatapplication/pdf
dc.languageeng
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 144, núm. 4 (2016): ABRIL 2016es-ES
dc.source0034-9887
dc.subjectCarcinoma, Hepatocellular; MicroRNAs; Polymorphism, Genetic; Polymorphism, Single Nucleotideen-US
dc.subjectCarcinoma, Hepatocellular; MicroRNAs; Polymorphism, Genetic; Polymorphism, Single Nucleotidees-ES
dc.titleASSOCIATION BETWEEN MICRORNA SINGLE NUCLEOTIDE POLYMORPHISMS AND THE RISK OF HEPATOCELLULAR CARCINOMAen-US
dc.titleAssociation between SNPs in miRNA3152andmiRNA449b and the risk to hepatocellular carcinomaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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