ADEQUATE DIAGNOSIS OF ACQUIRED HEMOPHILIA A

Importancia de la orientación diagnóstica en hemofilia A adquirida

Author
Casas Patarroyo, Claudia Patricia; Servicio de Hematología, Hospital San José. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia

Agudelo López, Claudia del Pilar; Especialista en Medicina Interna y Hematología. Organización Sanitas (Keralty)/Clínica Colsanitas. Bogotá, Colombia

Gálvez, Kenny; Servicio de Hematología, Hospital Pablo Tobón Uribe. Medellín, Colombia

Lagos Ibarra, Jimmy; Especialista en Hemato-oncología pediátrica. Hospital La Misericordia. Bogotá, Colombia

Martínez Rojas, Susan; NeuroEconomix. Bogotá, Colombia

Ibata Bernal, Linda; NeuroEconomix. Bogotá, Colombia

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6816
Abstract
Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.
 
Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.
 
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