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ADEQUATE DIAGNOSIS OF ACQUIRED HEMOPHILIA A

Importancia de la orientación diagnóstica en hemofilia A adquirida

dc.contributoren-US
dc.contributorNeuroeconomix, Bogotáes-ES
dc.contributorNovonordisk.es-ES
dc.creatorCasas Patarroyo, Claudia Patricia; Servicio de Hematología, Hospital San José. Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia
dc.creatorAgudelo López, Claudia del Pilar; Especialista en Medicina Interna y Hematología. Organización Sanitas (Keralty)/Clínica Colsanitas. Bogotá, Colombia
dc.creatorGálvez, Kenny; Servicio de Hematología, Hospital Pablo Tobón Uribe. Medellín, Colombia
dc.creatorLagos Ibarra, Jimmy; Especialista en Hemato-oncología pediátrica. Hospital La Misericordia. Bogotá, Colombia
dc.creatorMartínez Rojas, Susan; NeuroEconomix. Bogotá, Colombia
dc.creatorIbata Bernal, Linda; NeuroEconomix. Bogotá, Colombia
dc.date2019-01-10
dc.date.accessioned2019-11-11T18:27:51Z
dc.date.available2019-11-11T18:27:51Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6816
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111312
dc.descriptionAcquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.en-US
dc.descriptionAcquired hemophilia A (AHA) is a rare and life-threatening autoimmune hemorrhagic disorder where autoantibodies are developed against factor VIII. An early diagnosis is challenging and mandatory: an immediate hemostatic control is required to reduce morbidity and mortality. Laboratory features of AHA are: presence of autoantibodies against factor VIII, prolonged activated partial thromboplastin time (with normal prothrombin time and thrombin time) and decreased factor VIII levels. In some cases, the results of laboratory tests may be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and low sensitivity of the tests. This review highlights the importance of adequate screening in patients with suspected AHA to make an adequate diagnosis and reduce overall fatal outcomes.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 147, núm. 3 (2019): MARZO 2019es-ES
dc.source0034-9887
dc.subjectDiagnosis; Factor VIII; Hemophilic A; Hemorrhagic Disordersen-US
dc.subjectDiagnosis; Factor VIII; Hemophilic A; Hemorrhagic Disorderses-ES
dc.titleADEQUATE DIAGNOSIS OF ACQUIRED HEMOPHILIA Aen-US
dc.titleImportancia de la orientación diagnóstica en hemofilia A adquiridaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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