Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor íntima media carotideo

Author
Acevedo, Mónica; División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile.

Krämer, Verónica; División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile.

Tagle, Rodrigo; Departamento de Nefrología, Pontificia Universidad Católica de Chile, Santiago, Chile

Corbalán, Ramón; División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile.

Arnaíz, Pilar; División de Pediatría, Pontificia Universidad Católica de Chile, Santiago, Chile.

Berríos, Ximena; Departamento de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile.

Navarrete, Carlos; Departamento de Matemáticas, Universidad de la Serena, La Serena, Chile.

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1796
Abstract
TOTAL/HDL CHOLESTEROL RATIO AND NON HDL CHOLESTEROL AS PREDICTORS FOR INCREASED INTIMA MEDIA THICKNESS. Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. Aim: To determine which lipid indicators are better determinants of subclinical atherosclerosis, measured by intima media thickness (IMT) among subjects without demonstrated atherosclerosis. Material and methods: Lipid profile, height, weight, blood pressure and bilateral IMT, measured by ultrasound with  automatic border recognition software, were assessed in 770 men and 854 women aged 45±11 years, in Santiago de Chile.  Results: Mean total cholesterol was 202, HDL 50, LDL 121, triglycerides 157 and non-HDL cholesterol 152 mg/dl. Total/HDL cholesterol ratio was 4.3. Mean IMT was 0.62 mm. All lipid markers were significantly correlated with IMT. This correlation was higher for non-HDL cholesterol (r=0.24, p
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