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Variación de alelos del Gen receptor de Dopamina DRD4 en escolares chilenos de diferente origen étinico y su relación con riesgo de déficit atencional/hiperactividad.

dc.contributores-ES
dc.creatorRothhammer, Paula; Departamento de Psiquiatría, Escuela de Medicina Pontificia Universidad Católica de Chile
dc.creatorLagos, Liza Paz; Instituto de Alta Investigación, Universidad de Tarapacá Arica, Chile.
dc.creatorEspinosa-Parrilla, Yolanda; Instituto de Alta Investigación, Universidad de Tarapacá Arica, Chile.Institut de Biologia Evolutiva (UPF-CSIC), CEXS-UPF-PRBB, Barcelona, Catalunya, Spain
dc.creatorAboitiz, Francisco; Departamento de Psiquiatría, Escuela de Medicina Pontificia Universidad Católica de Chile
dc.creatorRothhammer, Francisco; Instituto de Alta Investigación, Universidad de Tarapacá Arica, Chile.Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile.Centro de Investigaciones del Hombre en el Desierto.
dc.date2012-09-26
dc.date.accessioned2019-11-11T18:28:01Z
dc.date.available2019-11-11T18:28:01Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1927
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111384
dc.descriptionDRD4 DOPAMINE RECEPTOR ALLELES IN CHILEAN STUDENTS OF DIFFERENT ETHNIC ORIGIN AND ITS RELATION WITH THE RISK FOR ATTENTION DEFICIT /HYPERACTIVITY DISORDER. Background: Worldwide diversity of alleles of D4 receptor gene (DRD4), linked to attention deficit hyperactivity disorder (ADHD), is mostly the result of length and single nucleotide polymorphisms in a 48-bp tandem repeat (VNTR). Alleles containing from two (2R) to eleven (11R) repeats have been identified. The most common are 4R, 7R and 2R. Aim: To study the association of ADHD risk with DRD4 genotypes in Chilean students. Subjects and methods: ADHD risk data were obtained through the abbreviated Conner’s Scale for School Teachers in  66 Aymara children (11 cases and 55 controls), 91 Rapa-Nui children (60 cases ad 31 controls) and 96 children from a mixed urban population from Santiago (51 cases and 45 controls). DNA extracted from saliva was amplified by polymerase chain reaction (PCR) to genotype the DRD4 VNTR. Results: The distribution of DRD4 alleles reveals that, beneath the 4R allele, 7R exhibits the second highest frequencies in Aymara and Santiago children. In Polynesian children, 2R ranks after 4R. A statistically significant association between ADHD risk and 2R/4R genotype was identified  in Polynesian children (p< 0.05; odds ratio =3.7). Conclusions: Different  DRD4 genotypes are associated with ADHD phenotype in Chilean populations, probably as a consequence of their initial colonization history. es-ES
dc.languagees
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4894
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4895
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4896
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4897
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4898
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4899
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/4900
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1927/5997
dc.sourceRevista Médica de Chile; Vol. 140, núm. 10 (2012): OCTUBRE 2012es-ES
dc.source0034-9887
dc.subjectAttention deficit disorder with hyperactivity; Child; Dopamine D4; Receptorses-ES
dc.titleVariación de alelos del Gen receptor de Dopamina DRD4 en escolares chilenos de diferente origen étinico y su relación con riesgo de déficit atencional/hiperactividad.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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