ASSOCIATION BETWEEN FTO (ns9939609) GENOTYPE AND ADIPOSITY MARKERS IN CHILEAN ADULTS
Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena.
Author
Petermann, Fanny
Villagrán, Marcelo
Troncoso, Claudia
Mardones, Lorena
Leiva, Ana María
Martínez, María Adela
Garrido-Méndez, Alex
Poblete-Valderrama, Felipe
Salas-Bravo, Carlos
Ramírez-Vélez, Robinson
Ulloa, Natalia
Peréz-Bravo, Francisco
Celis-Morales, Carlos; University of Glasgow
Abstract
Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p=0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p=0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p=0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors. Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p=0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p=0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p=0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.