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ASSOCIATION BETWEEN FTO (ns9939609) GENOTYPE AND ADIPOSITY MARKERS IN CHILEAN ADULTS

Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena.

dc.contributoren-US
dc.contributores-ES
dc.creatorPetermann, Fanny
dc.creatorVillagrán, Marcelo
dc.creatorTroncoso, Claudia
dc.creatorMardones, Lorena
dc.creatorLeiva, Ana María
dc.creatorMartínez, María Adela
dc.creatorGarrido-Méndez, Alex
dc.creatorPoblete-Valderrama, Felipe
dc.creatorSalas-Bravo, Carlos
dc.creatorRamírez-Vélez, Robinson
dc.creatorUlloa, Natalia
dc.creatorPeréz-Bravo, Francisco
dc.creatorCelis-Morales, Carlos; University of Glasgow
dc.date2018-04-19
dc.date.accessioned2019-11-11T18:28:16Z
dc.date.available2019-11-11T18:28:16Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6391
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111500
dc.descriptionBackground: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p=0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p=0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p=0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.en-US
dc.descriptionBackground: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p=0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p=0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p=0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6391/34465
dc.sourceRevista Médica de Chile; Vol. 146, núm. 6 (2018): JUNIO 2018es-ES
dc.source0034-9887
dc.subjectAdiposity; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Genotype; Obesityen-US
dc.subjectAdiposity; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Genotype; Obesityes-ES
dc.titleASSOCIATION BETWEEN FTO (ns9939609) GENOTYPE AND ADIPOSITY MARKERS IN CHILEAN ADULTSen-US
dc.titleAsociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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