Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostático maligno y benigno. Relación con la recidiva tumoral al año de la prostatectomía.

Author
Acuña, Pedro; Departamento de Urología, Corporación Nacional del Cáncer, Valparaíso, Chile

Ellwanger, Andrés; Interno, Escuela de Medicina, Universidad de Valparaíso

Ramírez, Angela; Interno, Escuela de Medicina, Universidad de Valparaíso

Cardemil, Felipe; Departamento de Ciencias Biomédicas, Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile.

Vega, Jorge; Departamento de Medicina Interna, Escuela de Medicina, Universidad de Valparaíso. Valparaíso, Chile.

Casalino, Renato; Sección de Anatomía Patológica, Corporación Nacional del Cáncer, Valparaíso, Chile.

Madrid, Eva; Departamento de Ciencias Biomédicas, Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile.Centro de Investigaciones Biomédicas, Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1481
Abstract
VASCULAR ENDOTHELIAL GROWTH FACTOR IN MALIGNANT AND NON MALIGNANT PROSTATIC TISSUE. ASSOCIATION WITH TUMOR RECURRENCE AT ONE YEAR AFTER PROSTATECTOMY. Background: Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor. Aim: To search for VEFG in prostatic tissue. Material and Methods: This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients. Results: PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p
Metadata
Show full item record