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dc.creatorPuga L,Barbara
dc.creatorCabrera C,María Elena
dc.creatorUndurraga S,María Soledad
dc.creatorEtcheverry B,Raúl
dc.creatorVacarezza Y,Ricardo
dc.creatorDucach G,Germán
dc.creatorToledo G,Humberto
dc.date2000-11-01
dc.date.accessioned2019-11-14T12:51:38Z
dc.date.available2019-11-14T12:51:38Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100002
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/114907
dc.descriptionBackground: The incidence of acute myeloid leukemia is 3 cases per 100.000 inhabitants/year and its five years event free survival is 15 to 20%. Since the incorporation of trans retinoic acid, event free survival of M3 acute myeloid leukemia is 80%. Aim: To report the results of acute myeloid leukemia treatment at the Hospital del Salvador, between 1990 and 1998. Patients and methods: The medical records of 117 patients (66 female, mean age 48.2 years), treated between 1990 and 1998 using PANDA protocol, were retrospectively reviewed. Immunophenotyping was done in 69 patients and cytogenetic studies were done in 65. Results: Sixteen percent of patients had M3 acute myeloid leukemia. The most frequent phenotype was the association of DR, CD34 plus a panmyeloid marker. DR and CD34 were negative in seven of nine patients with M3 acute myeloid leukemia. Cariotype was abnormal in 78% of patients. Complete remission was achieved in 65% of cases with a 13% of failures. Early mortality was 21.3% and decreased to 6.1% in the last three years. Infections and coagulation disorders were the main causes of death. Mean survival was 10.5 months. Five years event free survival was 11%. In M3 acute myeloid leukemia, the figure is 50%. Conclusions: Treatment results are less effective than protocols that consider more aggressive chemotherapeutic protocols or bone marrow transplantation. The reduction in early mortality is due to a better management of febrile neutropenia (Rev Méd Chile 2000; 128: 1191-98)
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98872000001100002
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.128 n.11 2000
dc.subjectAntineoplastic agents
dc.subjectcombined
dc.subjectChemotherapy
dc.subjectadjuvant
dc.subjectLeukemia
dc.subjectmyeloid
dc.subjectLeukemia
dc.subjectpromyelocytic
dc.subjectacute
dc.titleLeucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998


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