| dc.creator | Raddatz K,Verónica | |
| dc.creator | Durruty A,Pilar | |
| dc.creator | Briones B,Gloria | |
| dc.creator | López S,Gloria | |
| dc.creator | Soto I,Néstor | |
| dc.creator | García de los Ríos A,Manuel | |
| dc.date | 2001-08-01 | |
| dc.date.accessioned | 2020-02-17T15:26:50Z | |
| dc.date.available | 2020-02-17T15:26:50Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000800003 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/126986 | |
| dc.description | Background: Some adult, obese and diabetic patients, initiate their disease with a severe diabetic ketoacidosis without a precipitating factor and do not require insulin thereafter. These patients are classified as having a "non classical" diabetes mellitus. Aim: To study the clinical, immunological, genetic and metabolic features of patients with non classical diabetes mellitus. Patients and methods: Ten patients (9 men, aged 45±12 years old) with non classical diabetes mellitus were studied. Anti islet and anti glutamic acid decarboxylase antibodies (ICA and anti GAD), HLA DQ a arginine 52 and non aspartic ß57 were measured. Insulin secretion was measured by C peptide after glucagon injection and with the minimal model of Bergman. The latter model was also used to determine insulin sensitivity. Results: Three patients were immunologically classified as type 1, since they had positive ICA or antiGAD antibodies and type 1 genetics (neutral or susceptible HLA DQ a and ß). They had insulin secretion after glucagon stimulus (C peptide ranging from 2.2 to 7.5 pmol/ml), but an almost absent response to a glucose load. They were also insulin resistant (a sensitivity index ranging from 0.05 to 1.67 x 10-4 min/µU x ml). These three cases could be categorized as latent type 1. The other seven patients were ICA negative and antiGAD negative. Five had a susceptible HLA genotype for type 1 diabetes and two were neutral. All had insulin secretion after glucagon stimulation and a variable response to glucose. Six were insulin resistant (sensitivity index ranging from 0.32 to 1.29 x 10-4 min/µU x ml). One patient was insulin sensitive (sensitivity index of 3.83 x 10-4 min/µU x ml). Therefore all these patients were classified as type two diabetics with an atypical debut. Conclusions: Not all diabetics presenting with a severe diabetic ketoacidosis are type I. Among these, there are subjects with a latent type 1 diabetes or with an atypical type 2 diabetes (Rev Med Chile 2001; 129: 853-60). | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872001000800003 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.129 n.8 2001 | |
| dc.subject | Diabetes mellitus | |
| dc.subject | Diabetes mellitus, sudden onset | |
| dc.subject | Diabetic coma | |
| dc.subject | Diabetic ketoacidosis | |
| dc.title | Subtipos "no clásicos" de diabetes mellitus | |
