Background: During climacteric, the presence of disabling symptoms and the higher incidence of chronic diseases, may impair the job performance of women. Aim: To relate job performance levels with the climacteric period and associated factors in working women aged from 42 to 55 years old. Subjects and Methods: In a cross-sectional and correlative design, 64 secretaries at two public organizations at the Eighth Region of Chile, were assessed using the following instruments: Menopause-Specific Quality of Life Questionnaire (University of Toronto), adapted for Chile by PROSAM, Climacteric Self-care Questionnaire, Perceived Social Support Scale and Biodemographics Variables Questionnaire. A Perception of the Job Performance Scale was applied to the persons that superintended these woman. Results: The Department Heads or persons supervising these women, determined that most workers did their work well. The best evaluations were given by older bosses. Most women under study showed a moderate alteration of the Menopause Quality of Life. A deficit of self-care during the climacteric period was detected in 92.2%. The perceived social support from friends correlated with job performance. Menopause quality of life in its different domains had no correlation with job performance variable. Conclusions: No association between changes during the climacteric period and job performance was observed among women participating in this study (Rev Méd Chile 2005; 133: 315-22)