| dc.creator | Garcia,Rosane Scussel | |
| dc.creator | Araújo,Évelyn de Souza | |
| dc.creator | Dambrós,Betina Fernanda | |
| dc.creator | Schneider,Augusto | |
| dc.creator | Abib,Renata Torres | |
| dc.date | 2019-04-01 | |
| dc.date.accessioned | 2020-08-05T02:57:33Z | |
| dc.date.available | 2020-08-05T02:57:33Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-75182019000200168 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/150565 | |
| dc.description | ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Nutrición, Bromatología y Toxicología | |
| dc.relation | 10.4067/s0717-75182019000200168 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista chilena de nutrición v.46 n.2 2019 | |
| dc.subject | Cyclophosphamide | |
| dc.subject | Immunosuppression | |
| dc.subject | Vitamin C | |
| dc.subject | Weight loss | |
| dc.title | The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice | |
