A 120 days feeding trial was conducted to evaluate diets in which fish meal (FM) was replaced with meat and bone meal (MBM) or tuna byproduct meal (TBM) on growth performance, apparent digestibility and hematological parameters of juvenile spotted rose snapper (SRS) L. guttatus. Three isonitrogenous compounds (47.6-49.0%) and isoenergetic (20.9-22.9 kJ g1) diets were formulated. A control diet contained FM as a main protein source (D-FM) and two diets with 35% of fish meal protein replaced by MBM or TBM protein (D-MBM, D-TBM). Each diet was fed to triplicate groups of 20 SRS juvenile (initial weight 8.2 ± 0.02 g) to apparent satiation three times a day. Growth performance, hematological parameters and apparent digestibility of SRS fed D-MBM or D-TBM diets were not significantly different from D-FM diet. However, the whole body crude protein was significantly higher in D-MBM group than D-TBM group, and the values were comparable to D-FM group. Based on these results, the meat and bone meal is an economical and viable option, as tuna byproduct meal in practical diets for juvenile spotted rose snapper.