Diploid and triploid Crassostrea gigas oysters were cultured at three farms (Guasave, Navolato and Ahome) in Sinaloa, Mexico, to evaluate their growth and economic performances. Growth rate and survival of oysters were compared in long-line culture and were mostly affected (P < 0.05) by water parameters rather than ploidy or their interaction. The highest growth rates for shell length (8.01 mm month-1) and body weight (9.08 g month-1) were obtained for the Ahome/triploid group. Survival differed significantly from 98.6% for the Guasave/triploids to 76.69% for the Ahome/diploids. After the first production cycle, more than 80% of production costs represent the purchase of culture equipment and salaries contributed with around 9%. The Guasave farm produced the highest profits ($8,053.71 USD diploids, $8,182.19 USD triploids). Use of diploids starting the production cycle on October-November to avoid mortality and improve final profit is recommended.