The Chaco-Pampean plain is one of the greatest plains worldwide; present a wetland macro system (lagoons, marshes, rivers, streams, channels).  The water quality of these environments is diverse and has different trace elements natural (As, F, Mo and V) and anthropogenic (Cr, Cu and Pb). The Chaco Pampean plain has an important diversity of fish species however the species of commercial importance are limited. This paper presents the reviews of the studies related to the presence of trace elements in tissues of commercial fishes (shad Prochilodus lineatus and silversides Odontesthes bonariensis) in the Chaco-Pampean plain in recent decades and a discussion about associated information gaps is presented.The presence of trace elements in commercial fish muscle is a major problem for food security. The results showed that most of the elements present in shad are in lower levels than the maximum limits set by the Argentine Food Code (CAA, 2014). In the case of Pb present in the muscle of the shad, the determined values exceed those considered by the European Food Safety Authority. In the case of silversides the values of As, Pb, Hg are mostly lower than those maximum recommended by the Argentine Food Code. However, according to the European Food Safety Authority, the lower limit on the benchmark dose for a 10% response (BMDL) values associated with health risk for As.