Introduction: The Medicine career at the Pontificia Universidad Católica de Chile has undergone subsequent adjustments in its study plan. In this context, the theoretical-practical course of Obstetrics and Gynecology changed according to current paradigms in Medical Education. This research aims to describe the implementation and evaluation (student satisfaction and learning) of a blended learning (B-Learning modality) course in Obstetrics and Gynecology for medical students. Methods: A retrospective and descriptive design was used. Student satisfaction and learning was analized comparing the B-Learning to the face-to-face teaching previously used. Results: Students with the B-Learning modality reported dedicating more time to the course, better achievement of learning outcomes, and better perception of assessment and feedback. The average achievement of students with the B-Learning modality was slightly lower than that of other students; however, they demonstrated better performance on more complex assessment questions. Student satisfaction with the learning process was higher for B-Learning than face-to-face classes. Conclusions: B-Learning students had a similar level of learning attainment compared with the face-to-face modality but showed better performance on assessment questions that required a higher level of integration. This information is vitally important in the context of the SARS-CoV-2 pandemic, as much medical education has had to be carried out remotely during this time.