| dc.creator | Ruiz-Güereca, Duahmet A. | |
| dc.creator | Licea-Navarro, Alexei F. | |
| dc.creator | Sánchez-Saavedra, M. del Pilar | |
| dc.date | 2019-05-10 | |
| dc.date.accessioned | 2022-10-27T18:10:15Z | |
| dc.date.available | 2022-10-27T18:10:15Z | |
| dc.identifier | https://revistas.uv.cl/index.php/rbmo/article/view/1544 | |
| dc.identifier | 10.22370/rbmo.2019.54.1.1544 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/215039 | |
| dc.description | Tuberculosis is considered one of the most important epidemiological diseases worldwide. The current treatment for tuberculosis is a combination of antituberculosis drugs for at least 9 months. Nowadays, the search for new pharmacological agents for the treatment of tuberculosis is an urgent endeavor. Microalgae produce a wide variety of molecules that possess biological activities of pharmaceutical interest. Therefore, the objective of this work was to evaluate the antimycobacterial activity of hexane crude extracts of 6 microalgae: Chlamydomonas mexicana, Porphyridium cruentum, Isochrysis galbana, Rhodomonas sp., Aphanocapsa marina, and Nitzschia palea. All of the hexane extracts inhibited at least 90% of the growth of Mycobacterium tuberculosis H37Rv at a concentration of 100 μg ml-1. The hexane crude extract of I. galbana had the highest antimycobacterial activity displaying a percentage inhibition that was equal to that of the antituberculosis drug isoniazid and having a minimum inhibitory concentration of 50 μg ml-1. These findings demonstrate that microalgae are an excellent source for the search of novel antimycobacterial compounds. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Universidad de Valparaíso | es-ES |
| dc.relation | https://revistas.uv.cl/index.php/rbmo/article/view/1544/ART%20S%C3%A1nchez | |
| dc.rights | Derechos de autor 2019 Los autores que publican en la Revista de Biología Marina y Oceanografía transfieren automáticamente sus derechos de publicación a la Universidad de Valparaíso, asegurando todos los derechos de propiedad intelectual y difundir ampliamente el artículo y la revista en cualquier formato. Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons.(licencia de Atribución NoComercial 3.0 Unported). La Revista de Biología Marina y Oceanografía autoriza el uso de figuras, tablas y extractos breves de su colección de manuscritos, en trabajos científicos y educacionales, siempre que se incluya la fuente de información. | es-ES |
| dc.source | Revista de Biología Marina y Oceanografía; Vol. 54 Núm. 1 (2019); 82-90 | es-ES |
| dc.source | 0718-1957 | |
| dc.source | 0717-3326 | |
| dc.subject | Tuberculosis | en-US |
| dc.subject | Microalgae | en-US |
| dc.subject | Crude extract | en-US |
| dc.subject | Tetrazolium microplate assay | en-US |
| dc.subject | Antimycobacterial activity | en-US |
| dc.title | Evaluation of antimycobacterial activity from marine and freshwater microalgae | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
